Barcelona boss Ernesto Valverde makes just one change from the side that beat Atletico Madrid 2-0 in La Liga on Saturday night.
Nelson Semedo returns at right back in place of Spanish international Sergi Roberto for La Blaugrana's Champions League quarter final first leg against Manchester United.
Ole Gunnar Solskjaer also makes just one change, from their 2-1 defeat to Wolves eight days ago, with Marcus Rashford replacing Jesse Lingard.
MANCHESTER UNITED: De Gea, Young, Smalling, Lindelof, Dalot, McTominay, Pogba, Fred, Shaw, Rashford, Lukaku
SUBS: Romero, Jones, Rojo, Pereira, Lingard, Mata, Martial
BARCELONA: Ter Stegen, Semedo, Pique, Lenglet, Alba, Busquets, Arthur, Rakitic, Coutinho, Suarez, Messi
SUBS: Cillessen, Roberto, Umtiti, Alena, Vidal, Malcom, Dembele
