Samuel Umiti returns to the Barcelona starting XI for the first time since November 24th, as Ernesto Valverde makes three changes from the side that drew away in Lyon on Wednesday night.
French international Umtiti comes into defence in place of Clement Lenglet, with Arturo Vidal and Philippe Coutinho in for Sergi Roberto and Ousmane Dembele.
Sevilla boss Pablo Machin makes four changes to the side, that overcame Lazio, to progress to the last 16 of the Europa League in midweek , with Roque Mesa, Sergio Escudero, Franco Vazquez and Andre Silva all removed from the starting XI.
Midfielder Ever Banega comes back in, alongside Marko Rog, Maxi Wober and Quincy Promes
SEVILLA: Vaclik, Gomez, Kjaer, Mercado, Navas, Banega, Rog, Wober, Sarabia, Ben Yedder, Promes
SUBS: Lopes, Amadou, Mesa, Silva, Soriano, Munir, Vazquez
BARCELONA: Ter Stegen, Semedo, Pique, Umtiti, Alba, Busquets, Rakitic, Vidal, Coutinho, Suarez, Messi
SUBS: Pena, Murillo, Lenglet, Roberto, Alena, Malcom, Dembele