Valencia held Manchester United to a credible stalemate in their first away Champions League fixture for three years on Tuesday.
Valencia put in a spirited performance to keep United at bay, although neither team looked like scoring in what was a scrappy affair.
Los Che started Goncalo Guedes, Rodrigo Moreno and Michy Batshuayi in attack, while Jose Gaya and Cristiano Piccini returned to take both full-back berths.
United, meanwhile, had gone three games without a win to heap the pressure on manager Jose Mourinho, who went with stalwarts Marouane Fellaini and Alexis Sanchez as opposed to the likes of Fred and Anthony Martial.
Indeed, it was only at the start of the second half when Guedes carved out the game’s first real chance, his curler flying just wide of David de Gea’s goal.
Neto was then forced to tip over Paul Pogba’s powerful free kick, before a half-volleyed Batshuayi finish from near the penalty spot flashed over.
Romelu Lukaku cut an isolated figure in United’s attack for most part, although he did have an angled drive turned around the post by Neto.
Marouane Fellaini cleared a cross off the line late on, but Los Che were grateful to see Marcus Rashford’s free kick bounce off the crossbar and Lukaku send over a free header, leaving them third in Group H.
Manchester United 0-0 Valencia
Manchester United: De Gea; Valencia, Smalling, Bailly, Shaw; Fellaini, Matic, Pogba; Alexis (Martial 76), Lukaku, Rashford
Valencia: Neto; Piccini, Gabriel, Garay, Gaya; Parejo, Coquelin (Soler 78), Kondogbia, Guedes (Cheryshev 83); Batshuayi (Gameiro 73), Rodrigo
Referee: Vincic (SLO)