Jose Gaya and Dani Ceballos make their senior Spain debuts in tonight’s Nations League clash with Croatia.
Gaya is the next player to be experimented at left-back in Jordi Alba’s absence, with Marcos Alonso dropping to the substitutes’ bench.
Elsewhere, Ceballos replaces Thiago Alcantara in central midfield, while Marco Asensio comes in for Iago Aspas, allowing Rodrigo Moreno to move into the middle of Spain’s attack.
As for Croatia, who finished runners-up at the summer’s World Cup, Barcelona’s Ivan Rakitic and Real Madrid’s Luka Modric occupy two of their midfield spots.
La Roja have won just two of their six previous meetings with the Balkans but did beat England 2-1 at Wembley Stadium in their Nations League opener.
Spain: De Gea; Carvajal, Nacho, Ramos, Gaya; Ceballos, Busquets, Saul; Asensio, Rodrigo, Isco
Subs: Marcos Alonso, Azpilicueta, Morata, Albiol, Pau, Suso, Thiago, Sergi Roberto, Inigo, Kepa, Rodri, Aspas
Croatia: Lovre Kalinic; Vrsaljko, Matej Mitrovic, Vida, Pivaric; Rakitic, Brozovic, Kovacic; Modric, Perisic, Santini
Subs: Bradaric, Livaja, Pasalic, Rog, Barisic, Pjaca, Jedvaj, Cop, Milic, Letica, Livakovic, Badelj
Referee: Bastien (FRA)