Sevilla made history on Tuesday evening as they beat Manchester United 2-1 to reach the Champions League quarter-finals for the first time in 60 years.
Wissam Ben Yedder scored just two minutes after coming on as a substitute, before following up with a second goal moments later to also ensure Sevilla picked up their first-ever competitive win on English soil.
A calf injury ruled Jesus Navas out of a return to Manchester, where he spent four years with Pep Guardiola's City, while Paul Pogba was only named a substitute, the Frenchman having picked up a knock against Liverpool last weekend.
The tie was finely poised at 0-0 from a fortnight ago, but despite United widely being considered favourites to progress, Sevilla had other ideas, dominating the first half, even if only one of their attempts hit the target.
That should've acted as a wake-up call for Jose Mourinho's side, but while they continued to underestimate the visitors, the Andalusians' lack of firepower seemingly left extra time on the cards.
However, Vincenzo Montella's decision to replace Luis Muriel with Ben Yedder in a like-for-like swap proved inspired as the former Toulouse hitman slotted past David de Gea with only 15 minutes remaining.
He then managed to scramble home a second only two minutes later, not only cancelling out Romelu Lukaku's header in response but ultimately killing off the Red Devils.
Manchester United 1-2 Sevilla
Lukaku 84 (MU) Ben Yedder 74, 78 (S)
Manchester United: De Gea; Valencia (Mata 77), Bailly, Smalling, Young; Fellaini (Pogba 60), Matic; Lingard (Martial 77), Alexis, Rashford; Lukaku
Sevilla: Sergio Rico; Mercado, Kjaer, Lenglet, Escudero; Sarabia, N'Zonzi, Banega, Correa (Geis 89); Franco Vazquez (Pizarro 87); Muriel (Ben Yedder 72)
Referee: Makkelie (NED)