Sevilla were left to rue missed chances against Manchester United as David de Gea held them to a stalemate in the Champions League last 16 on Wednesday.
Two key stops from De Gea just before half-time appeared to take the wind from Sevilla's sails, although United's failure to score an away goal means the Andalusians only need one in the second leg, providing they don't concede.
Joaquin Correa and Ever Banega both started for Sevilla, dispelling doubts about their fitness, while the Red Devils began the game with Paul Pogba on the substitutes' bench, although the Frenchman was introduced early on to replace the injured Ander Herrera.
Vincenzo Montella's side went into the match on the back of three straight wins, but despite having 21 attempts at goal, they rarely looked like finding the back of the net.
For two of them, however, De Gea was on hand to first keep out Steven N'Zonzi's knock-on from an overhead kick, before saving the best for last, tipping over Luis Muriel's point-blank header.
Sevilla's lack of cutting edge played into United's hands as they were happy to leave the Sanchez Pizjuan with a clean sheet, although Romelu Lukaku's arm prevented him from firing home the game's only goal.
Sevilla 0-0 Manchester United
Sevilla: Sergio Rico; Jesus Navas, Mercado, Lenglet, Escudero; N'Zonzi, Banega (Pizarro 89); Sarabia, Vazquez, Correa; Muriel (Sandro 85)
Manchester United: De Gea; Valencia, Smalling, Lindelof, Young; Herrera (Pogba 80), Matic, McTominay; Mata (Martial 80), Lukaku, Alexis (Rashford 75)
Referee: Turpin (FRA)