Champions League holders Real Madrid will continue their defence of the competition against PSG while Barcelona and Sevilla face English opposition.
Barca will face English champions Chelsea in the last 16 while Sevilla will face Jose Mourinho’s Manchester United in a clash between two sides to have shared the last four Europa League titles.
Zinedine Zidane’s side are arguably involved in the tie of the round against the Parisians, with the European champions coming up against a side which bolsters Neymar, Kylian Mbappe and Angel Di Maria.
Elsewhere in the draw, last year’s beaten finalists Juventus will face Tottenham Hotspur while Porto play Liverpool, Basel take on Manchester City, Besiktas were paired with Bayern Munich while Shakhtar Donestk were drawn with Roma.
The first legs will be played over the weeks 13-14 and 20-21 February, with the return legs on 6-7 and 13-14 March.
UCL Last 16 draw
Basel v Man City
Besiktas v Bayern Munich
Juventus v Tottenham Hotspur
Manchester United v Sevilla
Porto v Liverpool
Real Madridv PSG
Shakhtar Donestk v Roma