Barcelona are without Andres Iniesta for tonight's crucial encounter with Villarreal, who lose Pablo Fornals after he fainted in training.
Iniesta is struggling with a calf strain and has not been risked for the trip to Villarreal, the midfielder joining Rafinha, Javier Mascherano, Ousmane Dembele and Samuel Umtiti on the treatment table.
He is replaced by Denis Suarez, who spent the 2015-16 campaign at La Ceramica.
Arda Turan and Gerard Deulofeu, meanwhile, have been dropped by Barca on technical grounds, amidst mounting speculation that they will leave in January.
Villarreal have personnel problems of their own, with captain Bruno Soriano among those missing out against the Catalans.
Starlet Fornals has also been ruled out after passing out in training and since being diagnosed with hypoglycaemia, a potentially-serious condition relating to low blood sugar.
The Yellow Submarine come into the match on the back of successive Liga defeats and have not beaten Barca since March 2008.
However, the League leaders are winless in two and faced with the pressure of not dropping points after Real Madrid and Valencia both emerged victorious.
Villarreal: Asenjo; Mario, Alvaro, Victor Ruiz, Jaume; Soriano, Rodri, Ruben Semedo, Trigueros; Raba, Bakambu
Subs: Barbosa, Marin, Rukavina, Bonera, Castillejo, Ramiro, Chuca
Barcelona: Ter Stegen; Sergi Roberto, Pique, Vermaelen, Alba; Rakitic, Busquets, Denis; Paulinho; Messi, Suarez
Subs: Cillessen, Nelson Semedo, Alcacer, Digne, Gomes, Vidal, Costas
Referee: De Burgos Bengoetxea