Only Sime Vrsaljko and Kevin Gameiro are missing for Atletico Madrid against Chelsea as Wanda Metropolitano hosts its first-ever Champions League game.
Vrsajlko and Gameiro were not included in Atleti’s squad for the match, paving the way for Juanfran Torres at right-back and Angel Correa up top.
Elsewhere, Diego Godin and Lucas Hernandez form a new-look partnership at centre-back, while Thomas Partey is preferred to Gabi Fernandez in midfield.
Chelsea, meanwhile, line up in a 3-4-1-2 formation as Cesc Fabregas plays behind Alvaro Morata and the returning Eden Hazard in attack.
The Blues lost their opening two games of the season but have gone on to win six of their last seven, including a 4-0 thrashing of Stoke City over the weekend.
Los Colchoneros, on the other hand, remain unbeaten this season, although three of their seven encounters have ended in draws.
These two sides last met in the 2013-14 Champions League semi-finals, when Atleti beat Chelsea 3-1 on aggregate to set up an all-Madrid final with arch-rivals Real for the first time ever.
Diego Costa will also be a spectator, just a day after swapping Chelsea for Atleti, while Fernando Torres is only a substitute against his former club.
Atletico Madrid: Oblak; Juanfran, Godin, Lucas, Filipe; Koke, Thomas, Saul, Carrasco; Correa, Griezmann
Subs: Moya, Savic, Gimenez, Gabi, Gaitan, Torres, Vietto
Chelsea: Courtois; Azpilicueta, David Luiz, Cahill; Moses, Kante, Bakayoko, Alonso; Cesc; Morata, Hazard
Subs: Caballero, Rudiger, Christensen, Zappacosta, Willian, Pedro, Batshuayi
Referee: Cakir (TUR)