Gerard Pique and Denis Suarez are Barcelona’s only survivors in defence and midfield against Real Betis as the Catalans have one eye on the Copa del Rey.
Betis, for their part, are bolstered by the return of Aissa Mandi in defence after the Algerian’s unsuccessful participation at the Africa Cup of Nations.
Real Betis: Adan; Pezzella, Mandi, Tosca; Piccini, Petros, Pardo, Ceballos, Durmisi; Alegria, Castro
Subs: Gimenez, Navarro, Bruno, Martinez, Donk, Nahuel, Zozulya
Barcelona: Ter Stegen; Vidal, Pique, Mathieu, Digne; Denis, Rakitic, Arda; Messi, Suarez, Neymar
Subs: Cillessen, Mascherano, Alcacer, Alba, Sergi, Gomes, Umtiti
Referee: Hernandez Hernandez