Pepe and Isco miss out of the Real Madrid XI to play Atletico Madrid in the Champions League quarter-final first leg, with Fernando Torres benched too.
Raphael Varane partners Sergio Ramos while Madrid’s midfield three is made up of Toni Kroos, Luka Modric and James Rodriguez.
Captain Iker Casillas returns in goal after sitting out the weekend win over Eibar, with Dani Carvajal and Marcelo rounding out the back four.
Cristiano Ronaldo, Karim Benzema and Gareth Bale form Los Blancos’ front three.
Atletico have Jan Oblak in goal and Juanfran, Miranda, Diego Godin and Guilherme Siqueira in defence, with a midfield made up by captain Gabi, Mario Suarez, Koke and Arda Turan.
Antoine Griezmann offers support to Mario Mandzukic in attack.
Atletico Madrid: Oblak; Juanfran, Miranda, Godin, Siqueira; Gabi, Mario, Koke, Arda Turan; Griezmann, Mandzukic
Subs: Moya, Gamez, Gimenez, Tiago, Raul Garcia, Saul, Torres
Real Madrid: Casillas; Carvajal, Varane, Ramos, Marcelo; Kroos, Modric, James; Bale, Benzema, Cristiano Ronaldo
Subs: Navas, Pepe, Arbeloa, Khedira, Illarra, Isco, Jese
Referee: Milorad Mazic [Serbia]