Barcelona start with Alexis Sanchez and Pedro in support of Lionel Messi for tonight’s game at Villarreal.
The game is the Catalans’ first to be played after the death of former Barca Coach Tito Vilanova, who passed away from cancer on Friday.
Barca go into the game in third place following wins this weekend for Real Madrid and Atletico Madrid.
Madrid dispatched Osasuna 4-0 on Saturday while Atletico took a 1-0 win from their visit to Valencia.
The leaders are now six points clear but a Barca victory would cut the gap to four points and restore the champions to second place.
Jose Pinto continues in goal with Dani Alves, Javier Mascherano, Marc Bartra and Adriano making up the back four.
Xavi Hernandez, Sergio Busquets and Andes Iniesta form the midfield trio with Alexis, Messi and Pedro in attack.
Villarreal can move two points behind Real Sociedad with a win and have Sergio Asenjo in goal and a back four of Mario, Mateo Musacchio, Gabriel and Bojan Jokic.
Bruno and Tomas Pina form the midfield partnership with Manu Trigueros and Cani joined by former Barca starlet Giovani dos Santos in support of Jeremy Perbet.
Villarreal: Asenjo; Mario, Musacchio, Gabriel, Jokic; Bruno, Pina; Trigueros, Cani, Giovani; Perbet
Barcelona: Pinto; Alves, Bartra, Mascherano, Adriano; Xavi, Busquets, Iniesta; Alexis, Messi, Pedro