Barcelona have made four changes from the side that drew with Atletico Madrid on Tuesday for tonight’s visit of Real Betis.
Out go Gerard Pique, Jordi Alba, Cesc Fabregas and Neymar with Marc Bartra, Adriano, Pedro and Alexis Sanchez taking their place.
That means Andres Iniesta will revert to midfield with Pedro and Alexis support Lionel Messi on either flank.
Pique misses out with a pelvis injury and is expected to be on the sidelines for the next four weeks.
Betis go with ex-Real Madrid goalkeeper Antonio Adan between the posts and a defence of Juanfran, Antonio Amaya, Jordi and Juan Carlos.
Alfred N’Daiaye, Lolo Reyes and Nono provide a midfield shield with Cedrick and Alvaro Vadillo supporting Leo Baptistao, on loan from Atletico Madrid.
Barcelona: Pinto; Alves, Bartra, Mascherano, Adriano; Busquets, Xavi, Iniesta; Pedro, Messi, Alexis
Betis: Adan; Juanfran, Amaya, Jordi, Juan Carlos; N’Diaye, Lolo, Nono;Vadillo, Cedrick; Baptistao