The Europa League last-16 draw throws up an all-Spanish tie between Athletic Bilbao and Valencia as Villarreal play Bayer Leverkusen and Sevilla face Basel.
The tie between Athletic Bilbao and Valencia sees the 2012 finalists take on the 2004 winners and serves as a continuation to Sunday’s La Liga fixture at San Mames.
Elsewhere, Villarreal’s reward for beating high-flying Napoli in the round of 32 is an equally-difficult pair of games against Leverkusen, while competition holders Sevilla lock horns with Basel, the latter of whom will host the final in May.
The first legs will be played on March 10, with the return games scheduled a week later.
Europa League last-16 draw in full:
Shakhtar Donetsk v Anderlecht
Basel v Sevilla
Villarreal v Bayer Leverkusen
Athletic Bilbao v Valencia
Liverpool v Manchester United
Sparta Prague v Lazio
Borussia Dortmund v Tottenham Hotspur
Fenerbahce v Braga