Carlo Ancelotti continues with a 4-3-3 formation as Real Madrid name Xabi Alonso, Luka Modric and Angel Di Maria in midfield.
It had been suggested the Italian could look to return to a 4-2-3-1 system to give game time to Isco but Marca reports Ancelotti has kept faith with the three-pronged forward line.
Gareth Bale will play down the right, Karim Benzema through the middle and Cristiano Ronaldo on the left.
Diego Lopez returns to goal after Iker Casillas came in for the Copa del Rey win over Espanyol.
Dani Carvajal and Marcelo get the nod on either side of defence with Pepe and Sergio Ramos form the centre-back partnership.
Marca says Granada also line up in a 4-3-3 formation with Roberto in goal and a back four of Allan Nyom, Diego Maniz, Jeison Murillo and Bryan Angulo.
Lucas Alcaraz has named Mohamed Fatau, Manuel Iturra and Recio as the midfield three with Piti, Youssef El-Arabi and Yacine Brahimi in attack.
Madrid: Diego Lopez; Carvajal, Pepe, Sergio Ramos, Marcelo; Xabi Alonso, Modric; Di Maria, Bale, Benzema, Ronaldo
Granada: Roberto; Nyom, Mainz, Murillo, Angulo; Fatau, Iturra, Recio; Piti, El-Arabi, Brahimi
