Pepe returns for Real Madrid against Athletic Bilbao with Raphael Varane dropping to the bench.
The Portugal international had been sidelined with injury in recent weeks but returns to partner Sergio Ramos, with Dani Carvajal at right-back and Marcelo on the left.
Iker Casillas continues in goal and the midfield is made up of Toni Kroos, Luka Modric and James Rodriguez.
The BBC are on show in attack, Gareth Bale and Karim Benzema joined by Cristiano Ronaldo.
Ernesto Valverde meanwhile names Gorka Iraizoz in goal with a back four of Oscar de Marcos, Carlos Gurpegi, Aymeric Laporte and Mikel Balenziaga.
Ander Iturraspe and Mikel Rico support Benat Extebarria, Iker Muniain and Markel Susaeta, and Guillermo Fernandez leads the line in the absence of Artiz Aduriz.
Real Madrid: Casillas; Carvajal, Pepe, Ramos, Marcelo; Kroos, Modric, James; Bale, Benzema, Ronaldo
Athletic Bilbao: Iraizoz; De Marcos, Gupergui, Laporte, Balenziaga; Iturraspe, Mikel Rico; Benat, Muniain, Susaeta; Guillermo
Referee: Jose Alejandro Hernandez Hernandez
